This gene may play a role in both UPR and ERAD.

Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system.

Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.

The full-length nature of all transcript variants has not been determined.

This article on a gene on human chromosome 16 is a stub.