UFC 121: Lesnar vs. Velasquez was a mixed martial arts event held by the Ultimate Fighting Championship on October 23, 2010, at the Honda Center in Anaheim, California, United States.

[4] UFC 121 featured the return of preliminary fights live on Spike TV.

[5] UFC Primetime also returned to promote the Brock Lesnar vs. Cain Velasquez title fight.

[6] Jon Madsen was expected to face Todd Duffee, but Duffee was forced off the card due to a lingering knee injury and was replaced by Gilbert Yvel.

[10] On October 4, 2019, Velasquez made his WWE debut confronting Lesnar on the first episode of Friday Night SmackDown on Fox, thus setting up the match at Crown Jewel for the WWE Championship where Lesnar defeated Velasquez in 88 seconds.