[3] UFC 181 was the organization's 300th event and was expected to be headlined by a Middleweight Championship bout between the current champion Chris Weidman and top contender Vitor Belfort.

[3] However, on September 22, it was announced that Weidman had suffered a broken hand and the bout was again rescheduled to take place at UFC 184.

The new main event was a Welterweight championship rematch between champion Johny Hendricks and number one contender Robbie Lawler.

[10] The unique poster and keyart for the event featured a comicbook style fight scene, drawn by noted DC Comics artist Howard Porter.

[12] On February 17, the Nevada State Athletic Commission ultimately decided to issue a nine-month suspension and fined her 30 percent of her purse ($2,400).