UFC 251: Usman vs. Masvidal was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on July 12, 2020 at the du Forum on Yas Island, Abu Dhabi, United Arab Emirates.

[7] The pairing first met at UFC 245, where Volkanovski defeated Holloway via unanimous decision to capture the title.

[8] Volkanovski indicated in late March that due to the COVID-19 pandemic, he would postpone his title defense on the initial June 6 date.

[9] A UFC Women's Flyweight Championship bout between current champion Valentina Shevchenko and Joanne Calderwood was expected to take place on the event's first date.

[10] However, Shevchenko was forced to withdraw from the event on March 31 due to a leg injury and the bout was postponed.

[18] However, it was announced on July 3 that Burns was pulled from the contest after he and his coach, Greg Jones, tested positive for COVID-19.

[21] The previously mentioned UFC Featherweight Championship rematch between Volkanovski and Holloway co-headlined the event.

Both of their bouts proceeded at a catchweight and they were each fined 20% and 30% of their individual purses, which went to their opponents Zhalgas Zhumagulov and Karol Rosa.