UFC 270: Ngannou vs. Gane was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on January 22, 2022, at the Honda Center in Anaheim, California.

[13] The Ultimate Fighter: Brazil 3 middleweight winner Warlley Alves was expected to face Jack Della Maddalena in a welterweight bout.

[14] However, Alves pulled out in early January due to undisclosed reasons and he was replaced by promotional newcomer Pete Rodriguez.

[25][26] A women's strawweight bout between Vanessa Demopoulos and Silvana Gómez Juárez was initially scheduled for UFC on ESPN: Kattar vs. Chikadze a week earlier, but it was pushed back to this event.

[31] Four-time Brazilian Jiu-Jitsu World Champion Rodolfo Vieira was expected to face Wellington Turman in a middleweight bout at the event.

It is important to note the amounts do not include sponsor money, discretionary bonuses, viewership points or additional earnings.