UFC 271: Adesanya vs. Whittaker 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on February 12, 2022 at the Toyota Center in Houston, Texas, United States.

[3] The pairing met previously in October 2019 at UFC 243, when then interim champion Adesanya knocked out Whittaker in the second round to unify the middleweight title.

[10] A potential middleweight title eliminator bout between Jared Cannonier and Derek Brunson was scheduled for UFC 270.

[12] 2016 Olympic silver medalist in wrestling Mark Madsen and Vinc Pichel were expected to meet in a lightweight bout.

[17] However in late January, Herman withdrew due to unknown reasons and was replaced by William Knight.