UFC 28: High Stakes was a mixed martial arts event held by the Ultimate Fighting Championship on November 17, 2000 at the Trump Taj Mahal in Atlantic City, New Jersey.

Under the sanctioned rules, this was the first event requiring competitors to wear trunks, gloves (and no other attire).

[2] The sanctioned rules also introduced new strict weight classes, resulting in the first and only UFC Super Heavyweight bout ever, between Josh Barnett and Gan McGee.

The event was headlined by the return of former Heavyweight Champion Randy Couture, who had relinquished his title in 1998 to return to competitive wrestling and because of contract disputes—and he regained his championship belt by defeating Kevin Randleman.

UFC 28 also featured the first UFC appearances of Andrei Arlovski, Renato "Babalu" Sobral, Chris Lytle, Josh Barnett, and Gan McGee, and the sole appearances of Alex Stiebling, Ben Earwood, Aaron Brink, and Matt Hughes's twin brother, Mark Hughes.