UFC 280: Oliveira vs. Makhachev was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on October 22, 2022, at the Etihad Arena in Abu Dhabi, United Arab Emirates.

[4] Beneil Dariush, who is scheduled to face former KSW Featherweight and Lightweight Champion Mateusz Gamrot, revealed in mid-September that he was expected to serve as backup to this contest.

[11] They were originally scheduled to meet at UFC Fight Night: Gane vs. Tuivasa a month earlier, with Chookagian pulling out once due to undisclosed reasons, only to return as a replacement for her own substitute.

[18] In turn, the pairing was cancelled altogether as Trabelsi pulled out due to contractual issues with ARES FC and Porter opted to pursue a later fight, rather than a replacement barring unforeseen circumstances.

[24] In turn, Almeida was booked against Maxim Grishin at UFC Fight Night 214 in a catchweight of 220 pounds, after Abdurakhimov withdrew again for unknown reasons.