UFC on ESPN: Thompson vs. Holland (also known as UFC on ESPN 42) was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on December 3, 2022, at the Amway Center in Orlando, Florida, United States.

[2][3] The promotion has previously contested three events at Kia Center in Orlando, most recently in February 2018 for UFC on Fox: Emmett vs.

[5] They were originally booked to fight at UFC on ESPN: Vera vs. Cruz four months earlier, but Nunes withdrew due to injury.

[6] A middleweight bout between Jack Hermansson and Derek Brunson was expected to take place at the event.

[8] A women's flyweight bout between Tracy Cortez and Amanda Ribas was expected to take place at the event.