The early mission of the CEPES was to encourage cooperation, to disseminate information, and to research modern trends in higher education within the Europe Region.
In the early 1990s, with the fall of the communist regimes in Central and Eastern Europe, the role of UNESCO-CEPES extended its round has been broader.
on this endeavour, the UNITWIN/UNESCO Chairs Programme constituted "a major breakthrough with regard to the reinforcement of inter-university co-operation at the sub-regional, regional and interregional levels as a means to improve the quality in higher education as well as to strengthen national capabilities for higher level training and research in the developing countries."
From the late 1990s, the Centre gradually more co-worked on European Union projects aimed at the reform of higher education in Eastern and Central Europe and reinforced its cooperation with international organisations such as World Bank, OECD, and others.
CEPES will focus on addressing the needs of higher education of UNESCO's Member States in Central, Eastern and South-East Europe.