1UW4, 2WJV, 4CEK, 4CEM26019326622ENSG00000151461ENSMUSG00000043241Q9HAU5A2AT37NM_015542NM_080599NM_001081132NP_056357NP_542166NP_001074601Regulator of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene.

[5][6][7] This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance.

When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.

It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p.

[7] UPF2 has recently been shown to alter adult behavior via alterations in hippocampal synaptic spine density and the late long-term potentiation of neurons.