According to the announcement published at the time, it was to be "organized out of the staff and physical resources of the existing museum and herbaria at UPLB, including the hortorium and culture collections of separate departments in the Colleges of Agriculture, Forestry, and Sciences and Humanities.

The Institute of Biological Sciences' small Room C329 is a treasure trove which houses 74,454 century old plants showcasing Philippine biodiversity, as second-largest collection of herbarium.

[21]The Hortorium is an in-situ collection of around 400 living plants, mostly of food, medicinal, tonic and ornamental value, and maintained and cared for in a small portion of land adjacent the Molawin River that traverses the UPLB campus.

Despite being a disturbed freshwater ecosystem, the Hortorium still harbors new and unique organisms such a minute cockroach,[22] several species of predatory mites,[23] and a "pirate" ant.

Dr. Rabor led more than 50 biodiversity field expeditions in his 20 years of research, collecting more than 60,000 specimens which was deposited in major Philippines museum and the US.

More than 10,000 bird and 4,300 mammal specimens have been deposited at the UPLB Museum of Natural History which have become material for taxonomic and ecological studies, historical DNA sequencing, and phylogenetic analyses.

[117] As a public service institution dedicated to biodiversity conservation education, the museum regularly holds exhibits, special tours, seminars, training programs, and provide technical assistance to local government units, other organizations and communities.

For scientists and researchers, the museum is able to provide services such as scientific name verification, biological specimen identification, and provision of microbial cultures.

[118] Aside from hosting its own scientific gathering, i.e. CLADES 2017, to gather stakeholders of the Philippine natural history collections system and enhance the overall appreciation of natural history collections for increased networking and collaboration,[119] the Museum also collaborates with other scientific organizations and societies in the holding of meetings and conferences, e.g. 25th SEAZA Conference (2018)[120] and the 11th ANRRC International Meeting Philippines (2019) which highlighted the roles of biological resource centers, that includes museums, in the conservation, preservation, and utilization of animal, plant and microbial resources.

Its most active personnel and experts not only contribute to the expansion of the collections but also lend credence to the experience and capability of the museum in terms of natural history research and studies; taxonomy and systematics; biodiversity conservation and education.