[4] UPMC Presbyterian also features a state verified adult Level 1 Trauma Center, 1 of 3 in Pittsburgh.

[8][9] UPMC Presbyterian is also connected via enclosed pedestrian bridges and tunnels to UPMC Montefiore hospital, UPMC Western Psychiatric Hospital, the Eye & Ear Institute, Falk Clinic, the University of Pittsburgh School of Nursing's Victoria Hall, the University of Pittsburgh's (Pitt) Lothrop Hall student residence, and multiple university biomedical science towers.

Lyle had attended medical school years earlier, but failed out due to the prejudice of male administrators.

[17] The University of Pittsburgh School of Medicine then worked out informal agreements for teaching and staffing privileges with a number of local hospitals to train their medical students and residents.

[27] In 1947, Jonas Salk took a job at the University of Pittsburgh as an associate professor of bacteriology and the head of the Virus Research Lab.

[29][30] In the 1970s, a new model of administration, in which clinical revenues were invested into research, was implemented at Western Psychiatric under the leadership of Thomas Detre.

[35] In 1981, a pioneering surgeon called the Father of Transplantation, Dr. Thomas E. Starzl came to the hospital, on condition that he would be free of administrative tasks and able to focus on medicine.

Byers W. Shaw Jr. and Henry T. Bahnson successfully completed the world's' first simultaneous heart and liver organ transplant on six-year-old Stormie Jones at the Children's Hospital of Pittsburgh.

Starzl was the head of transplantation at the hospital until 1991 when he stepped down from clinical and surgical duties and shifted all of his focus to research.

[40] On September 9, 1984, a story was published by author Andrew Schneider in The Pittsburgh Press criticizing the hospitals' use of unsupervised first and second-year residents in the emergency departments.

The opening was delayed after a slight issue led to a leaking pipe, damaging the lobby at Presbyterian.

[43] The Main Tower had a rooftop heliport with connections to UPMC Presbyterian Hospital that were accessed through multiple floors.

[49] In January 2001, American Nobel Prize laureate, Herbert A. Simon underwent surgery at UPMC Presbyterian to remove a cancerous tumor in his abdomen.

[56] The helipad is operated by Stat Medevac, a Pittsburgh-based emergency transport organization who also maintains a dispatch center at UPMC Presbyterian.

[59][60] The next year, in June 2018, American model and Miss USA 1971 winner, Michele McDonald underwent a life-saving double lung transplant at UPMC Presbyterian Hospital in Pittsburgh.

[61] On October 27, 2018, a man with anti-Semitic views entered Tree of Life synagogue and started to open fire upon the worshippers inside.

[83] The hospital is designed to highlight the world-famous transplant program at UPMC, made famous by pioneer, Dr. Thomas Starzl.

[85] The addition will add 900,000 square feet to space on the UPMC Presbyterian campus, without adding any beds overall.

[86][87][88] In May 2021, UPMC announced that the new date for construction would be near the end of 2022 due to a mixture of both the COVID-19 pandemic and labor shortages.

[89] In December 2021, UPMC announced that they had bought another section of land adjacent to the site and started meeting with local community and planning boards with the hope to begin construction on the new hospital by the end of 2022.

[106] In 2020 the hospital was recognized by Human Rights Campaign Foundation as a "Top Performer" in their forward thinking LGBTQ policies and initiatives.

Pennsylvania Lieutenant Governor, John Fetterman attended and made the statement "In 10 years, I haven't seen UPMC do the right thing.