Curt Chaplin served as the unseen "Cartoon Announcer", providing voice-overs for the block's opening, closing and commercial bumpers, continuing in this role until 1992.

[1][2] Well-known properties like Scooby-Doo, Huckleberry Hound, Yogi Bear, Space Ghost, The Smurfs, and Jonny Quest shared space with lesser-known properties like Wheelie and the Chopper Bunch, Inch High, Private Eye, Dynomutt, Dog Wonder, and countless others, as well as numerous spin-offs of The Flintstones such as The Pebbles and Bamm-Bamm Show.

In the fall, Cartoon Express introduced two original series, Itsy Bitsy Spider and Problem Child (based on the film franchise).

Teenage Mutant Ninja Turtles became the new marquee series on the block, and USA also acquired the broadcast rights to Terrytoons shorts like Deputy Dawg and Mighty Mouse.

The Cartoon Express left the station for the last time on September 15, 1996; the USA Action Extreme Team would inherit the Cartoon Express's timeslots and continue for two more years before ending in late 1998 as USA Networks cut its animation blocks on most of its outlets, including Sci-Fi Channel's Animation Station.