[clarification needed] Since 1996, Monomoy has conducted over three-hundred law enforcement boardings, including the interception and seizure in 1998 of 920 pounds of cocaine off the coast of Puerto Rico.

Between 1994-96, Monomoy participated in Operation Able Manner, which resulted in the rescue of seventy-one migrants in the Caribbean whose vessels were foundering, for which the ship was awarded a Coast Guard Meritorious Unit Commendation.

According to military sources the two Riverine Command Boats (RCBs) were on a routine transit from Kuwait to Bahrain, which serves as the home port for Task Force 56 under the Fifth Fleet.

They were scheduled to refuel with the Monomoy during the transit, however, one RCB developed an engine problem and both boats stopped to solve the mechanical issue.

Monomoy, noting the delay of the RCBs at the rendezvous point and tracking their progress notified the group's parent unit, Task Force 56.7.

Monomoy's notification, combined with the actions of a female Navy petty officer who activated an Emergency Position-indicating Radio Beacon (EPIRB) signal, while in Iranian custody, aided the search and rescue operation.Monomoy was subsequently tasked with Combat Search and Rescue efforts inside Iranian territorial waters off Farsi Island to attempt to locate, and if possible, recover the RCB crews.