USCGC Grand Isle (WPB-1338) was an Island-class patrol boat operated by the United States Coast Guard.

The Island-class patrol boats were constructed in Bollinger Shipyards, Lockport, Louisiana.

It has two 99 kilowatts (135 PS; 133 shp) 3304T diesel generators made by Caterpillar; these can serve as motor–generators.

[4][5] The Island-class patrol boats have maximum sustained speeds of 29.5 knots (54.6 km/h; 33.9 mph).

As of December 2016, the United States Government transferred Grand Isle from the United States Coast Guard to the Pakistan Navy's Maritime Security Agency under the Office of International Acquisition’s Excess Defense Articles (EDA) Program, together with sister ship Key Biscayne.