USCGC Reliance (WMEC-615) is a United States Coast Guard medium endurance cutter.

Constructed by Todd Shipyards in Houston, Texas and commissioned in 1964, she was originally homeported in Corpus Christi, Texas.

Her duties included offshore oil rig inspections, fisheries, counter drug, alien migrant interdiction, marine pollution patrols, and search and rescue.

Reliance has been homeported in Yorktown, Virginia, Port Canaveral, Florida, New Castle, New Hampshire and Portsmouth, New Hampshire.

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