USCGC Vigorous (WMEC-627) is a United States Coast Guard Reliance Class medium endurance cutter.

She was decommissioned for modernization at the United States Coast Guard Yard in Curtis Bay, Maryland, in early 1992 and was recommissioned on 11 January 1993.

On 11 February 2013, the Vigorous stood by the disabled 102,000-ton cruise ship Carnival Triumph adrift in the Gulf of Mexico waiting to be towed.

Although the fire was automatically extinguished and there were no injuries to passengers or crew, it resulted in a loss of propulsion and power to all support systems.

During May 2014, the Vigorous was spearheading the search for the Yacht Cheeki Rafiki one thousand miles east of Cape Cod, which went missing on a delivery voyage from Antigua to Southampton, England.