[1] In 1918, it created the four-year Bachelor of Science in pharmacy degree program.

Later, in 1968, the school introduced the nation's first clinical pharmacy program, and the first Master of Science in radiopharmacy.

In 1974, the school relocated to the USC Health Sciences campus, where students and faculty had access to multidisciplinary medical facilities and the Los Angeles General Medical Center.

In 1988, USC established the nation's first PharmD/MBA dual degree program, training students in both pharmacy and business administration.

On November 17, 2022, the University of Southern California released an announcement [4] stating that the school will be renamed the USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences and will receive a $50 million endowment for student scholarships, faculty recruitment and integrating a university-wide research infrastructure related to biomedical innovation across USC’s University Park and Health Sciences campuses.Patient care settings include Keck Hospital of USC, Norris Comprehensive Cancer Center, Los Angeles General Medical Center, Huntington Hospital, Edward R. Roybal Comprehensive Health Center, and safety-net clinics including JWCH Institute, QueensCare, AltaMed Health Services.