In October 1922, she departed Hampton Roads, Virginia, for the Mediterranean where she served with the U. S. Naval Detachment in Turkish Waters until July 1923.

Later in August and September, Barry operated as a plane guard in the Atlantic for the U.S. Army's "Around the World Flight" and was stationed between Labrador and Nova Scotia, Canada.

Upon completion of maneuvers, she returned to the Atlantic and was assigned to Rotating Reserve Destroyer Squadron 19 at Norfolk, 20 December 1932.

Barry was recommissioned at Norfolk 20 June 1933 and on 1 July sailed for San Diego to Join Destroyer Division 7, Scouting Force.

Still on duty there when the United States entered World War II, she was assigned escort and anti-submarine warfare missions against the German submarines in the Atlantic.

Early in 1942, Barry operated in the Caribbean escorting convoys between Guantánamo Bay, Cuba, and Panama; and Curaçao and Trinidad.

Between July and November 1943, she served as a unit of TG 21.14, an offensive antisubmarine patrol which operated along the North Atlantic convoy lanes.

Barry underwent conversion to a high-speed transport at Charleston Navy Yard, 31 December 1943 – 17 February 1944 (reclassified APD-29, 15 January 1944).

Barry was towed to the anchorage at Kerama Retto 28 May, and was found too extensively damaged to warrant repair or salvage.