[1] Boston cruised in the West Indies (July 1799 – June 1800) protecting American commerce against French privateers.

[2][3] On 17 November stopped a schooner with questionable papers and put a prize master on board and sent her in to Cape Francois for verification.

[4] In company with USS General Greene, on 1 December 1799 she recaptured Danish brig "Flying Fish", captured by André Rigaud's barges, but with questionable crewing and other oddities (possibly French owned),[5] and assisted in the recapture of the American schooner Weymouth the next day, which had been captured by French privateer Hope.

[6][7] Shortly after that she encountered French Navy corvette Diligente, but took no action as she was convoying troops of General Toussaint for the Haitian Revolution, seemingly carrying a US pass.

[12] On 26 March she captured French sloop "Le Heureux" off Cape Tiburon, Hispaniola, she was sunk on 2 April, being old and leaky.

[16] She cruised along the American coast until departing Boston 19 September[17] when she sailed to the Guadeloupe Station in the West Indies.

[18] During her West Indian cruises Boston captured seven additional prizes (two in conjunction with USS General Greene).

[25] Considered not worth repairing on the outbreak of the War of 1812, she remained at Washington until 24 August 1814 when she was burned to prevent her falling into British hands.