USS Cochrane (DDG-21) was a Charles F. Adams-class guided missile destroyer built for the United States Navy in the 1960s.

The Charles F. Adams class was based on a stretched Forrest Sherman-class destroyer hull modified to accommodate smaller RIM-24 Tartar surface-to-air missiles and all their associated equipment.

The turbines were intended to produce 70,000 shaft horsepower (52,000 kW) to reach the designed speed of 33 knots (61 km/h; 38 mph).

The primary armament of the ships was the Tartar surface-to-air missile designed to defend the carrier battle group.

Cochrane appears in the original Hawaii Five-O (1968 TV series) season 8 episode Murder: Eyes Only.