They were followed by the Fremont volunteers and Cyane's detachment returned aboard to sail for San Blas, where a landing party destroyed a Mexican battery on 2 September.

Entering the Gulf of California, Cyane seized La Paz and burned the small fleet at Guaymas.

She returned to Norfolk 9 October 1848 to receive the congratulations of the Secretary of the Navy for her significant contributions to American victory in Mexico.

She bombarded and destroyed Greytown, Mosquitia on 13 July 1854, in retaliation for an incident where local protesters had thrown a broken bottle at Solon Borland.

In 1863, during the Civil War, the Cyane prevented the sloop J. M. Chapman from being used as a Confederate privateer when her armed boarding party took control of the ship as it was preparing to leave San Francisco.

[3] Except for necessary overhauls, the Cyane was constantly employed on the coasts of North and South America until she was decommissioned and placed in ordinary at Mare Island Navy Yard on 20 September 1871.