USS Drusilla (SP-372) was a patrol vessel that served in the United States Navy from 1917 to 1918.

Drusilla was built as a private motorboat of the same name in 1914 by the New York Launch and Engine Company at Morris Heights in the Bronx, New York.

On 22 May 1917, the U.S. Navy acquired her under a free lease from her owner, A. J. Drexel of Radnor, Pennsylvania, for use as a patrol boat during World War I.

Assigned to the 4th Naval District, Drusilla served on the section patrol in the Delaware Bay area, performing harbor entrance and submarine net patrol duties for the remainder of World War I. Drusilla was decommissioned on 10 December 1918.

The Navy returned her to Drexel on 12 December 1918.