Post-war, she was borrowed by the United States Coast Guard and also served as a radar picket ship on the Distant Early Warning Line.

Seaman Second Class Falgout was killed in action in the Naval Battle of Guadalcanal on 12 November 1942, while serving on the USS San Francisco when he remained at his gun, firing at a Japanese aircraft until it crashed into his station.

Completing her shakedown, she began Atlantic convoy escort duty out of Norfolk, Virginia, and New York to North African ports, making eight such voyages between 3 February 1944 and 2 June 1945.

Before the concentrated antiaircraft fire of Falgout and the other escorts could drive them off, they blew up the transport SS Paul Hamilton, sank the destroyer USS Lansdale, and damaged several of the merchantmen.

Falgout arrived at Balboa, Panama Canal Zone, 25 June 1945, where she remained until 13 December, making good will visits to Nicaragua and Costa Rica, joining in defense problems, and training submarines.

Falgout was on loan to the United States Coast Guard between 24 August 1951 and 21 May 1954, in commission, as WDE 424, and commanded by CDR G. L. Rollins, USCG for duty as an ocean station vessel out of Tacoma, Washington.