USS Holder (DE-401) was an Edsall-class destroyer escort built for the United States Navy during World War II.

Named for Lieutenant (junior grade) Randolph Mitchell Holder (a naval aviator who was reported missing during the Battle of Midway), she was the first of two U.S.

After completion of her shakedown cruise, Holder departed 24 March escorting a convoy bound for Mediterranean ports.

Though fires spread and flooding was serious, Holder's crew remained at their guns to drive off the attackers without damage to the convoy.

A 95'-long section of the stern portion of Holder's hull was used to repair USS Menges; the remainder was sold for scrap to John A. Witte, Staten Island, New York on 19 June 1947.