From 3 March to 20 August 1944 General William Mitchell made five round trip transport voyages out of Norfolk, Virginia and New York to Casablanca and Liverpool, carrying fighting men to the North African Theater and participating in the buildup prior to the Allied invasion of Northern France.

On the return leg of these frequent voyages, she carried casualties and rotation troops home to the United States, ensuring a steady flow of men and equipment between America and war-torn Europe.

These troops debarked at Ulithi and the Philippines in the summer of 1945, and the ship returned to San Francisco 6 December 1945 at war's end filled with homeward-bound warriors.

From April 1946 until 1949 General William Mitchell sailed from West Coast ports and shuttled troops and supplies to and from Japan, China, Guam, and Hawaii.

General William Mitchell continued to transport men and material from West Coast ports to Japan and Korea, supporting the United Nations forces in the latter country.