USS George F. Pierce (ID-648), sometimes reported as SP-648,[1] was a cargo ship that served in the United States Navy from 1918 to 1922.

George F. Pierce was built as the commercial wooden-hulled steam cargo and passenger ship SS George F. Pierce by William G. Abbott in 1914.

In 1918, the U.S. Navy purchased her from the Milford and Philadelphia Freight Line Company of Philadelphia, Pennsylvania, for use during World War I and assigned her the naval registry identification number (Id.

Assigned to the 4th Naval District, George F. Pierce served as a passenger ship and supply boat in the Philadelphia area for the next four years.

She was sold to L. N. Hearn of Milford, Delaware, on 5 June 1922.