[1] USS Great Sitkin supported USN operations in several major theatres, including the Mediterranean, the Atlantic, Cuban Missile Blockade, Guantanamo Bay, and the Vietnam War.

Great Sitkin's pattern of operations for the next few years took her to the Caribbean and the Panama Canal Zone on ammunition replenishment trips, as well as twice to Gibraltar.

USS Great Sitkin cruised the Caribbean during the next several weeks carrying reserve ammunition for American ships on quarantine duty off Cuba.

On 5 April 1963, Great Sitkin suffered slight damage during a fire of unknown origin while tied up at the Main Ship Repair Corporation in Brooklyn, New York.

After a 3-month overhaul in the Bethlehem Shipbuilding Corporation, Hoboken, N.J., in December 1966 USS Great Sitkin participated in training exercises off Guantanamo Bay, Cuba.