Remaining in the Reserve Destroyer Force until 10 September 1921, she sailed from San Diego that date for the Puget Sound Navy Yard.

Back at Norfolk 26 February 1943, she steamed from there to NS Argentia, Newfoundland, to operate with Bogue, one of the new escort carriers designed to hunt German submarines in the North Atlantic.

Subsequently, until the fall of 1943, Greene escorted a fast troop convoy from Norfolk to the United Kingdom and return, and operated off Bermuda.

On 20 October the group sank U-378 in 47-40 N., 28-27 W. Greene returned to Charleston 19 January 1944 for conversion to high speed transport, and was designated APD-36 on 1 February 1944.

On 14 August, when she left the staging area at Propriano, Corsica, and landed American and Canadian troops on the Levant and Port-Cros islands off the coast of France between Toulon and Cannes.

Greene's troops were assigned to the mission of seizing the strategic islands and silencing long range coastal batteries thought to be emplaced there.

That day, the islands were secured - many of the German "guns" turned out to be stove pipes - and the stage was set for 15 August assault on the mainland.