She sailed from New York on 20 May 1815 to lead the squadron in terminating piratical acts against American merchant commerce by Algiers and other Barbary States.

[3] Guerriere arrived at Algiers on 28 June 1815, ready to act with her squadron for the capture of every Algerian ship that entered port unless the Dey ratified the terms of a peace treaty sent him by Decatur.

Having enforced the peace in less than six weeks from time of sailing from the United States, she combined with the entire Mediterranean Squadron naval force assembled at Gibraltar under Commodore William Bainbridge.

The 18 warships, including ship-of-the-line Independence, five frigates, two sloops-of-war, seven brigs, and three schooners, was the largest fleet ever collected under the American flag in the Mediterranean Sea to that time.

For the next seven years she served as a schoolship in the Norfolk Navy Yard, training classes of midshipmen before the permanent establishment of a naval academy.

In the following two years, she watched over American commerce, including the whaling fleet, along the western seaboard of South America and westward to the Hawaiian Islands.