USS Home was a large steamship purchased by the Union Navy during the American Civil War.

She was placed into service as a hospital ship assigned to support the fleet blockading the ports of the Confederate States of America.

Home — a screw steamer — was built as Key West in 1862 at the Brooklyn Navy Yard, New York.

Home was assigned by Rear Admiral John A. Dahlgren as a rest ship, to which the exhausted crews of the steaming monitors could retire after the fierce bombardments of early September.

Redocumented Key West, she returned to merchant service; she was stranded and lost off Cape Hatteras on 12 October 1870.