During October and November 1962 the destroyer escorted Pacific-based amphibious forces to the Panama Canal Zone as part of the US Navy's Cuban Missile Crisis operations.

Hull's 1965 Seventh Fleet tour was the first of six Vietnam War deployments, during which she fired tens of thousands of five-inch shells in support of forces ashore and helped rescue several downed U.S. aviators.

Hull was its test ship for seagoing trials, after which it was expected that several of these guns would be installed on board destroyers of the new Spruance class.

She began her final deployment in September 1982, steaming to the Western Pacific by way of Alaska, rescuing five Vietnamese refugees at sea in October and then moving further west to serve in the Indian Ocean and Arabian Sea as part of the battle group built around the nuclear-powered aircraft carrier Enterprise.

[5] Returning to the United States West Coast in April 1983, Hull immediately commenced inactivation preparations.