In early August she steamed from the Florida coast westward and almost immediately captured two small schooners off Mobile, Alabama.

By the end of July she had taken three prizes, Confederate steamers Adela and Reliance and British schooner Agnes, carrying cargoes of cotton, rosin, and other commodities.

Before the end of the year, she captured two additional blockade runners, schooners Courier and Ariel, trying to run into Mobile with cargoes of lead, tin, medicines, wines, and coffee.

During 1863 she captured two Confederate ships, Minnie and A. J. Hodge; two British schooners, Surprise and Ascension; and Spanish steamer Union.

Departing Panama 5 June, she discovered survivors of the wrecked steamer Golden Rule on Roncador Island.

After completing two passenger runs to Boston, Massachusetts, Huntsville escorted monitor Nausset to Philadelphia where she arrived 22 August.