After shakedown, Isle Royale moved to Long Beach to begin her services to Pacific Fleet destroyers, supplying them with parts and vital repair facilities.

The tender sailed for Pearl Harbor on 8 February 1963 and for the next seven months served the destroyers roaming the Pacific on their vital peacekeeping mission.

However, upon arriving Pearl Harbor, she received orders to proceed on to the Philippines where she tended ships of the 7th Fleet fighting in Vietnam.

She remained in the Orient operating primarily out of Subic Bay tending the destroyers of the 7th Fleet until her return to Long Beach on 12 April 1967.

Custody was transferred to the Maritime Administration, for disposal; Isle Royale was sold by MARAD on 1 December 1977, to Waterman Supply Co. who stripped her any usable parts before selling the hulk to International Steel Co. for scrap.