In a gun duel first with schooners Somers, Tigress, Porcupine, and sloop Trippe, and then, as the tide of battle turned, with Perry's flagship Niagara, Lady Prevost suffered damage to her masts and superstructure and her captain, Lieutenant James Buchan, was mortally wounded.

While the ship's second-in-command, Lieutenant Frédérick Rolette continued the fight, he was also wounded in an explosion and the vessel was compelled to surrender with the rest of her squadron.

In company with Niagara, Scorpion, and Trippe under command of Captain Jesse D. Elliott, she sailed into Lake St. Clair on 29 September to cut the supply lines of the British Army attempting to invade western New York.

For the remainder of the War of 1812, the squadron operated on Lakes Erie and Huron, cooperating with the Army commanded by General William Henry Harrison.

Following the end of the war in 1815, Lady Prevost was burned and sunk by the Americans at Erie, Pennsylvania, but was raised later that year and converted into a merchantman.