After 1953, she alternated operations along the west coast of the United States and in Hawaiian waters, with regular deployments to the western Pacific with the Seventh Fleet.

As a member of this task group, Maddox took part in the preparation and the covering operations for the Mindoro and Luzon invasions, 4 November 1944 to 21 January 1945.

During this period she served in the screen and on picket station in the South and East China Seas, while carrier-based planes struck air and naval bases from Saigon to Formosa.

Departing on 14 March, the destroyer steamed off the Japanese home islands where she was on picket station during the air strikes on Kyushu and southern Honshu.

For almost three months, until 13 June 1945, Maddox continued to provide support for this campaign in the form of shore bombardment and carrier screening for raids on Kyushu and Shikoku.

Following the Japanese surrender, Maddox continued to patrol off Japan until departing Tokyo Bay 20 September with military passengers for the United States.

She operated there until 1 February 1946, when she returned to the Far East to support the movement of naval occupation forces between Shanghai, Qingdao, and Taku in China, and the ports of Pusan and Jinsen in Korea.

On 1 May 1950, Maddox departed San Diego for the Far East, arriving Hong Kong 26 June, the day after the commencement of hostilities in Korea.

Departing for South Korea the next day, she acted as plane guard and antisubmarine screen for the aircraft carriers USS Valley Forge and HMS Triumph.

She continued this assignment, which included a diversionary bombardment of Samchok coordinated with the Inchon landings on 15 September, until departing for the United States early in January 1951.

As on her second Korean deployment, the destroyer again guarded the fast carriers along the eastern coast of Korea; participated in shore bombardments, this time as far north as Hungnam, and served, for a two-week period, in the Taiwan Patrol Force.

On this tour, which lasted until 5 December, she took part in antisubmarine warfare tactics and attack carrier exercises off Kyushu, Korea, and Luzon as well as operating with the Taiwan Patrol Force.

On 4 August, another DESOTO patrol off the North Vietnamese coast was launched by Maddox and USS Turner Joy, in order to "show the flag" after the first incident.

At 0127 Washington time, Herrick sent a cable in which he admitted that the attack may never have happened and that there may actually have been no North Vietnamese craft in the area: "Review of action makes many reported contacts and torpedoes fired appear doubtful.

After arrival at Long Beach, Maddox remained in a leave and upkeep status until mid‑January 1965, then conducted training exercises and repairs in preparation for her next WestPac deployment.

After conducting upkeep and local exercises off the California coast, summer 1966 saw her engaged in a training cruise for midshipmen which included a trip to Pearl Harbor.

After a successful tour consisting primarily of providing gunfire support, interrupted by a visit to Singapore and a crossing of the Equator on 8 February 1967, Maddox departed Subic Bay, Philippine Islands, for home by way of Australia, New Zealand, and Pearl Harbor.

On 6 July 1972 she was transferred to Taiwan, commissioned into the Republic of China Navy, and renamed ROCS Po Yang (DD-10) and served with the Naval Weapons school.