On 7 June, Manley got underway from San Juan, Puerto Rico for a goodwill tour that took her to Lisbon, Amsterdam, Kiel, and Copenhagen.

In the early morning hours of 12 December, the destroyer was broadsided by a tremendous wave, killing two, injuring several others, and impacting heavy damage to the galley, radio and radar rooms when she suffered flooding.

Enduring northwesterly gusts up to 80 knots, Manley battled through heavy rain squalls and mountainous seas toward Lisbon to arrive at night on 13 December for emergency treatment of the injured and repairs to the vessel.

On 6 June 1958, Manley set sail with the squadron for an Atlantic Fleet operation that included midshipmen training, implementation of the President's people-to-people programs, and visits to foreign ports of call.

She visited among other ports, Kiel, Germany and Copenhagen, Denmark, and Antwerp, Belgium while escorting the aircraft carrier USS Lake Champlain (CV-39).

Returning to Norfolk on 2 October, she was soon underway with the USS Intrepid to join the Second Fleet in maneuvers off the coast of San Juan, Puerto Rico.

Then, she headed eastward to Cardiff, Wales, and participated in experimental antisubmarine warfare patrols and attack team exercises en route to stateside.

One of those pilots, now retired Captain Bill Brandel of Fairfax, Virginia, appeared at the Capitol 2001 Reunion on Sunday, 28 October 2001, nearly thirty years later, to extend his gratitude to several of those who participated in his rescue.

On 13 January 1964, Manley dispatched her then Executive Officer, Lieutenant Commander Joseph E. Murray, Jr. to negotiate with armed rebels in Zanzibar.

Following routine upkeep in Charleston, she resumed operations off the Atlantic coast in May and on 6 January 1965 returned to the Mediterranean, representing the United States during the tenth anniversary celebrations of CENTO in Iskenderum, Turkey.

During her homeward voyage, Manley spotted the collision of Kaskaskia and the Liberian tanker SS World Bond near St. Helena.

On 21 November, Manley relieved USS Hull in Da Nang as a unit of TU 70.8.9, a gunfire support group of the Seventh Fleet.

Awarded the Navy Unit Commendation for sustained meritorious service in operations against the enemy during her deployment in Southeast Asia, Manley returned to Charleston in May 1967.

Extensive improvements to sensors, weaponry, communications, and crew habitability were accomplished and on 19 April 1971, she was recommissioned and joined CruDesFlot 4 in Norfolk.

With an increasing naval presence in the Caribbean Sea, the destroyer operated throughout the area visiting Curaçao, Antilles, Limón, Costa Rica, and Santo Tomas de Castilla.

Following a successful refit and sea trials, Manley was assigned to Newport, Rhode Island, and conducted workup ops in the Narragansett area preparing for REFTRA in Guantanamo Bay.

She visited all of the Med ports, assisted in evacuation of civilians from Beirut, Lebanon, during terrorist activities, and transited the Indian Ocean arriving after fifty days at sea in Karachi, Pakistan.