The contract to build Missouri was awarded to the Electric Boat Division of General Dynamics Corporation in Groton, Connecticut on 14 August 2003.

[citation needed] Sections of the submarine were built at both shipyards with final assembly completed at one or the other.

[10] In March 2014 Missouri made an 11-week-long surge deployment in the Northern Atlantic, just three months after her previous deployment[11] possibly linked to the Annexation of Crimea by the Russian Federation, which took place in March 2014.

[13][14] On 26 January 2018, Missouri sailed into her new homeport of Pearl Harbor, Hawaii from Groton, Connecticut.

[15] On 31 March 2022, Missouri returned to Pearl Harbor after a deployment to the 7th fleet.