The Neosho, (the third US Navy ship to bear the name), with a cargo capacity of 135,000 barrels (21,500 m3), immediately took up her duties of delivering oil, the life blood of the warship, when and where it was needed.

From Samoa she continued on to Suva, thence to Espiritu Santo where she served as station tanker, occasionally deploying for fueling at sea operations, until 26 March 1943.

From there she supported the vessels of TFs 50 and 58 as they helped secure the Marianas and blocked the enemy's efforts to open aerial and maritime lanes to carry reinforcements and supplies to the defenders of their constantly receding empire.

On 26 August Neosho arrived at Manus whence she supplied the fleet as land forces secured the southern Palaus and invaded the Philippines at Leyte.

Neosho was sold in 1947 to the Socony-Vacuum Oil Company, and renamed SS Tascalusa, then to Ascalusa in 1963, the ship was finally scrapped in February 1964.