After shakedown off Portsmouth, New Hampshire, Odax got underway 19 September 1945 for Guantanamo Bay Naval Base in Cuba to provide services to the Fleet Training Group.

On 30 October 1945, she departed for Key West, Florida, for duty with the Fleet Sonar School and conducted operational training until September 1946.

Completing conversion in August 1947, the first of the GUPPY submarines, she departed for Key West for extensive research development work.

During 1956 she received new equipment of improved design at the Charleston Naval Shipyard and departed in December, bound for the North Atlantic, to operate with the British Fleet.

In October and November 1967, Odax provided services to the Fleet Training Group in Guantanamo Bay, Cuba for a period of 8 weeks.

During this deployment, while submerged in the Norwegian Sea, Odax learned that her home port had been changed to Key West, Florida.

Early in the year she took time out to visit New Orleans for Mardi Gras, and to submerge in the Mississippi River for publicity purposes.

In March and April 1972, in her last military duty, Odax provided NATO services during a seven-week unsupported deployment to the Eastern Atlantic.