On 2 April 1991 Pittsburgh and Louisville conducted submarine-launched Tomahawk missile attacks against Iraq during Operation Desert Storm.

On 25 February 2019, Pittsburgh returned to her homeport at Naval Submarine Base New London after completion of her final deployment.

[5] The submarine then arrived at Bremerton, Washington on 28 May 2019, for a months-long inactivation and decommissioning process.

[6] Pittsburgh was officially deactivated on 17 January 2020 at the Undersea Warfare Museum in Keyport, Washington, and awaited the Submarine Recycling Program at Puget Sound Naval Shipyard in Bremerton, Washington.

She was later decommissioned on 15 April 2020 and the crew released, 37 years to the day of her keel was laid down.