USS Preston was a blockade-running steamer originally named Annie that was captured by the Union Navy during the American Civil War.

She was placed in service on the Gulf of Mexico by the Union Navy as a gunboat during blockade operations against the Confederate States of America.

She was purchased by the Navy from the New York City Prize Court in December 1864 and was renamed Preston on 2 February 1865.

Assigned to the West Gulf Blockading Squadron, Preston departed New York City on 16 February and arrived at New Orleans, Louisiana on 9 March.

This article incorporates text from the public domain Dictionary of American Naval Fighting Ships.