The first USS Prometheus was a brig in the United States Navy from 1814 to 1818.

Prometheus was built by William Seguin, Philadelphia, Pennsylvania; purchased in 1814 by the Navy from Messrs. Savage and Dryan, the original owners, as the brig Escape; commissioned and renamed Prometheus, she was fitted out at Philadelphia by Master Commandant Joseph J. Nicholson.

Senators Eligius Fromentin and James Brown to Havana.

She sailed for Europe on 14 August 1816 to take Edward Coles, special messenger from the President of the United States to the Emperor Alexander I of Russia, returning to Boston, Massachusetts, on 25 November.

This article incorporates text from the public domain Dictionary of American Naval Fighting Ships.