USS Rattlesnake was the brig Rambler built in Medford, Massachusetts, in 1812 that the United States Navy purchased in July 1813.

Captain Benjamin Rich sold his brig Rambler to Amos Binney, the agent for the United States Navy on 3 July 1813 for $18,000, exclusive of armament.

[5] Rattlesnake's depredations ended (arguably) on 22 June when the 50-gun British frigate Leander captured her off Cape Sable, the southern point of the island of the same name which lies off Nova Scotia.

The letter from Captain George Collier of Leander is dated 11 July and states that Rattlesnake was armed with 22 guns, all of which she had thrown overboard during the chase, and that she had a crew of 131 men.

[8] The Vice admiralty court reported the name of Rattlesnake's master as J. Renshaw, and describes her as a brig of 280 to 300 tons (bm), of 14 guns and 130 men.