In June, she completed another North Atlantic run, this time to the United Kingdom, and in July, she screened larger ships in coastal and Caribbean Sea training operations.

Assigned to the Northern Attack Group, Roe screened the transports to Mehedia, then provided gunfire support for the troops as they pushed to take Port Lyautey in the Sebou River and the Salé airfield.

She arrived off the assault area on the night of 7/8 November, ahead of the main group, and with her SG radar, attempted to locate the beacon submarine, Shad.

Shortly after sunrise she assisted Savannah in temporarily silencing hostile fire from the Kasba, an old citadel situated on a cliff commanding the mouth of the Sebou.

In the winter and the following spring, 1943, Roe again performed escort work with tanker runs to Gulf of Mexico and Caribbean oil ports and resupply and reinforcement convoys to Casablanca.

Early on 10 July, she and Swanson moved toward Porto Empedocle, an Italian motor torpedo boat base guarded by a minefield 24 miles west of Licata, to investigate small pips which had registered on their radar screens.

The destroyers defended themselves and in the process shot down one Junkers Ju 88 with 13 rounds of proximity-influence-fused 5 inch fire to prove the worth of the new fuse in antiaircraft fighting.

From there, and other New Guinea ports and anchorages, she escorted 7th Phib Force ships transporting Allied troops up the coast and through neighboring islands, and provided gunfire support in target areas.

Patrol, picket, and escort duties then kept her shuttling between and amongst the Marshall and Mariana Islands, primarily the latter, until early December when she joined TG 94.9 for a bombardment of Iwo Jima.

In late April, she returned to the Volcano-Bonin area for radar picket and search and rescue operations during air strikes against the Japanese home islands.