USS Shelton (DE-407) was a John C. Butler-class destroyer escort built for the United States Navy during World War II.

After fitting out and loading stores, Shelton steamed out of port on 21 April, in company with Edmonds bound for Bermuda on her shakedown cruise.

She departed Boston on 16 June en route to San Diego via New York City, Hampton Roads, and Balboa, Panama Canal Zone.

Shelton was then assigned as a unit in the screen for Task Force 57 (TF 57) — composed of five carriers — and routed to Seeadler Harbor, Admiralty Island.

The DE was still off Morotai on 3 October in the screen for the escort carriers Fanshaw Bay and Midway when they were attacked by the Japanese submarine RO-41 at location 2°33′N 129°18′E / 2.550°N 129.300°E / 2.550; 129.300.