Following shakedown training in Long Island Sound, and the waters off Panama and Oahu, Tirante departed Pearl Harbor for Japan on 3 March 1945.

On 31 March, Tirante shelled and sank a 70-ton lugger with five-inch (127 mm) and 40-millimeter gunfire and, on 1 April, missed an LST-type vessel with a spread of three torpedoes.

In spite of possible enemy radar or patrolling planes or ships, she closed the coast and penetrated the mine- and shoal-obstructed waters within the ten-fathom curve line.

As she headed back out to sea at flank speed, Tirante launched a spread of torpedoes that hit and destroyed both pursuers.

En route to Midway Island, she captured two Japanese airmen (bringing her prisoner total to five) and concluded her first war patrol on 26 April.

She crept into Ha Shima harbor, some seven miles (11 km) from Nagasaki and picked out the 2200-ton Hakuju Maru moored alongside a colliery.

Tirante captured a dozen in this manner and destroyed two heavily armed picket boats with surface gunfire before returning to Guam on 19 July.

Eventually sailing for the east coast of the United States, Tirante moored at the Washington Navy Yard in October, at which time Commander Street received his Medal of Honor in a White House ceremony.

Subsequently converted to greater underwater propulsive power (GUPPY IIA) configuration, Tirante was recommissioned on 26 November 1952, at the Portsmouth Naval Shipyard.

After conducting her shakedown to Bermuda and operating in the Atlantic as far north as Iceland, the submarine returned to the east coast of the United States to prepare for her first deployment with the Sixth Fleet.

Decommissioned at Key West, Florida, on 1 October 1973, and struck from the Naval Vessel Register the same day, Tirante was sold on 11 April 1974 to Union Minerals and Alloys Corporation of New York, for scrapping.