USS Wissahickon was a Unadilla-class gunboat that was built for service with the United States Navy during the American Civil War.

Commissioned in November 1861, she initially served in the Gulf of Mexico and on the Mississippi River, where in April–July 1862 she participated in the capture of New Orleans, bombardment of Grand Gulf, two runs past the Confederate fortifications commanding the river at Vicksburg and a battle with the ironclad CSS Arkansas.

After repairs at Philadelphia from August–October 1862, Wissahickon joined the blockade of the coasts of South Carolina, Georgia and eastern Florida.

She took part in bombardments of Fort McAllister, Georgia, in late 1862-early 1863 and in the destruction of the privateer Rattlesnake (ex-CSS Nashville) on 28 February 1863.

Wissahickon spent the rest of the Civil War patrolling off South Carolina and in expeditions into the inland waters of that state and Georgia.