USS Zigzag (SP-106) was an armed motorboat that served in the United States Navy as a patrol vessel from 1917 to 1919.

Zigzag was a wooden-hulled motorboat completed in May 1916 by the A. E. Luders Construction Company of Stamford, Connecticut.

Zigzag subsequently was anchored in the North Beach Basin, Key West, Florida, awaiting disposition, when a hurricane battered the Florida Keys on 9 September 1919 and swept through the yacht basin.

On 10 September 1919, eight section patrol (SP) boats, including Zigzag, were found dashed to pieces on the seawall.

Salvage crews later hauled the tangled wreckage from the water and burned it, retaining only the machinery to survey for future disposal.